Clinical Analysis & Research Applying Mass spectrometry & Bioinformatics at Akademiska
The main focus of CARAMBA is to perform pre-clinical and clinical research, targeting endogenous and exogenous molecules, with the overall goal to improve human health care and disease prevention.
We also aim at implementing state-of-the-art as well as novel mass spectrometry and bioinformatics-based methods for use in routine clinical applications.
Torbjörn Åkerfeldt, MD
Medical management responsible physician
Acting Section Head, Chief
E-mail: [email protected]
Phone: +46 18 6114272
Mats Gustafsson holds the first Swedish professorship in Medical Bioinformatics (2008) and is also co-director of the In vitro and systems pharmacology facility which is part of SciLifeLab. Having a strong engineering background as a former professor of signal processing at the Department of Engineering Sciences, he is currently working on new integrated experimental-computational approaches for accelerated drug development and disease understanding including biomarker identification using machine learning. These approaches are mainly related to systemic molecular profiling methods (DNA methylation, mRNA, protein, metabolite) as well as phenotypic approaches based on label free video microscopy and more specific molecular readouts. Currently the main disease areas are cancer, neurodegeneration and bacterial infections. One overarching goal is to accelerate the modelling understanding and control of biological processes involved in human diseases via phenotypic and systemic (system wide) measurements and computational analyses. Another overarching goal is to understand and resolve fundamental theoretical and computational problems of central importance in the field of Medical Bioinformatics. Currently, the efforts are mainly focused on improved computational methods to achieve better label free video microscopy monitoring of growing cell cultures, in vitro analysis & optimisation of drug combinations, in vitro systems pharmacology using different profiling techniques, and network biology approaches enabling improved molecular understanding and prediction of different disease states.
With a background in bioengineering, bioinformatics and molecular biotechnology, Stephanie Herman has recently joined CARAMBA as a PhD student. Her shared focus and interests’ lies in the challenges provided by the data complexity and size of large-scale metabolomic studies and analyses of clinical metabolic data from patient diagnosed with various neurological diseases. Stephanie is part of work package 5 in the EU Horizon 2020 project PhenoMeNal, where they intend to develop a cloud-based e-infrastructure that enables scientists and health care providers to process and analyse medical metabolomics data for improved health care. Previously, Stephanie was part of the Uppsala iGEM team 2013 and project leader in the Uppsala iGEM team 2014, where she competed in the worldwide competition in Synthetic Biology hosted by Massachusetts Institute of Technology (MIT).
Best Technical Solution – OpenHack 2017
June 7, 2017Stephanie participated in OpenHack Uppsala 2017 together with her brother and two friends. They created an application that matches your abilities with mined skill keywords in job ads from Arbetsförme...
The Uppsala team presented at the Vårmöte klinisk kemi
April 6, 2017The Uppsala team presented at the Vårmöte klinisk kemi, 5-7 April in Tylösand, Sweden. Here Torbjörn is presenting our MS based assays for analysing PEth (a marker for alcohol consumption measured in ...
Payam and Stephanie presenting on PhenoMeNal workshop in Halle, Germany
April 4, 2017The Uppsala team presented at the PhenoMeNal Workflow Workshop, 4-5 April in IPB Halle, Germany. The presentations covered the two workflows which have been developed by the Uppsala team in PhenoMeNal...
CARAMBA members are regularly publishing in high ranked journals!
Entrance 61, 3rd Floor
751 85 Uppsala
General enquiries: [email protected]
Telephone: 018-471 00 00
Uppsala University, Box 256